Rapid Mixer Granulator (RMG) — Manufacturer, Supplier & Exporter in India

The Rapid Mixer Granulator (RMG) — also known as the High Shear Mixer Granulator — is the most important piece of equipment in pharmaceutical wet granulation. It combines dry mixing, binder addition, wet massing, and granulation in a single GMP-compliant vessel, significantly reducing processing time and improving granule quality compared to older granulation methods.

As a trusted Rapid Mixer Granulator manufacturer, supplier and exporter in India, Bipin Pharma Equipment has supplied RMGs to hundreds of pharmaceutical facilities across India and 25+ countries.

What is a Rapid Mixer Granulator?

The RMG is a batch-type, high-shear mixing and granulation machine. It consists of a stainless steel bowl, a bottom-driven main impeller (with two or three blades), and a side-mounted high-speed chopper. The impeller creates a fluidized mixing zone, while the chopper breaks down wet lumps to produce uniform granules. The entire process — from dry mixing to wet granulation — happens in the same sealed bowl, minimising contamination risk and reducing batch cycle time.

Working Principle of Rapid Mixer Granulator

Stage 1 — Dry Mixing

API and excipients (lactose, MCC, starch, etc.) are charged into the RMG bowl and dry mixed at low impeller speed for 3–5 minutes. The impeller creates a vigorous circulation pattern, distributing all ingredients uniformly before the wet phase begins.

Stage 2 — Binder Addition and Wet Massing

Binder solution (aqueous PVP, HPC, starch paste, or granulation solvent) is added — either manually through the top port or via a spray nozzle. The impeller speed is increased, and the chopper is activated. The binder distributes through the powder bed, and wet massing begins. The high shear and chopper action transform the wet mass into granules.

Stage 3 — End-Point Determination

Granulation end-point is determined by monitoring power consumption of the impeller motor (current rise indicates optimal granule formation), or by taking periodic samples to assess granule size and texture. Experienced operators also use visual and tactile assessment ("hold test"). Accurate end-point control is critical — over-granulation produces hard, dense granules that compress poorly.

Stage 4 — Discharge

Wet granules are discharged from the bottom outlet valve of the RMG bowl directly into the Fluid Bed Dryer's product container (bowl) for drying. The RMG-to-FBD transfer is usually done via a direct coupling or a flexible transfer tube to maintain GMP containment.

Key Features of Bipin Pharma RMG

• cGMP / WHO-GMP Compliant — SS 316L bowl and contact parts, mirror-polished Ra ≤ 0.8 µm
• Bottom-driven impeller — no shaft seal inside the product zone, eliminating leakage and contamination
• Variable Frequency Drive (VFD) — precise impeller and chopper speed control
• Chopper — side-mounted high-speed chopper (1450 / 2900 RPM) for lump breaking
• Top cover — sealed hinged top with spray nozzle port for binder addition
• Discharge valve — GMP-compliant bottom outlet with pneumatic actuation
• Safety interlocks — cover open detection, impeller overload protection
• CIP compatibility — spray nozzles for validated cleaning, compliant with 21 CFR Part 11
• Documentation — DQ/IQ/OQ/PQ package available

Technical Specifications

RMG in the Wet Granulation Line

Why Choose Bipin Pharma Equipment as Your RMG Manufacturer?

• 25+ Years of Experience — deep expertise in pharmaceutical granulation systems since 1995
• Full Line Supply — RMG + FBD + Multi Mill + Vibro Sifter + Blender as a matched granulation line
• Custom Bowl Sizes — from 10 L R&D scale to 1200 L production scale
• GMP Documentation — complete DQ/IQ/OQ/PQ, FAT at our facility
• After-Sales Support — installation, commissioning, operator training, spare parts