What equipment is required for a pharmaceutical tablet manufacturing plant?

A complete tablet plant needs: Rapid Mixer Granulator (granulation), Fluid Bed Dryer (drying), Multi Mill (size reduction), Vibro Sifter (classification), Double Cone Blender (lubrication blending), IPC Bins (transfer), Tablet Press (compression), and optionally a Coating Pan. Supporting utilities include Purified Water system, HVAC, clean compressed air, and dust collection.

What is the sequence of tablet manufacturing process?

The standard wet granulation tablet manufacturing sequence is: 1) Dry mixing in RMG → 2) Wet massing + granulation in RMG → 3) Drying in FBD → 4) Dry milling in Multi Mill → 5) Sifting in Vibro Sifter → 6) Lubrication blending in Double Cone Blender → 7) Transfer via IPC Bin → 8) Tablet compression → 9) Coating (if applicable) → 10) Packaging.

How much space is required for a tablet manufacturing plant?

Space requirement depends on batch size and number of products. A small-to-medium tablet plant (batch size 50-200 kg) typically requires 3000-6000 sq ft of GMP manufacturing space, including: granulation room (RMG + FBD), dry processing room (Multi Mill + Blender), compression room, coating room (if applicable), and supporting areas (change rooms, corridors, utility rooms). Contact Bipin Pharma Equipment for a detailed plant layout proposal.

Complete List of Pharmaceutical Equipment for a Tablet Manufacturing Plant

Tablet manufacturing is the most common pharmaceutical dosage form globally, accounting for over 60% of all medicines produced. Setting up a complete pharmaceutical tablet manufacturing plant requires a carefully selected and matched set of equipment across granulation, drying, blending, compression, coating, and packaging stages. This guide provides the complete equipment list for a GMP-compliant tablet plant.

As a leading pharmaceutical equipment manufacturer in India, Bipin Pharma Equipment manufactures most of the core equipment required for a tablet plant — from Rapid Mixer Granulators and Fluid Bed Dryers to Multi Mills, Vibro Sifters, Blenders, and Coating Pans.

Complete Tablet Manufacturing Equipment List

Stage 1 — Granulation Equipment

Equipment	Function	GMP Material
Rapid Mixer Granulator (RMG)	Dry mixing of API + excipients; wet massing; granulation with binder	SS 316L bowl and contact parts
Binder Preparation Vessel	Prepare aqueous binder solution (PVP, HPC, starch paste)	SS 316 jacketed vessel

Rapid Mixer Granulator (RMG)

High-shear mixing and wet granulation. Available 10 L to 1200 L. VFD impeller and chopper, SS 316L bowl, cGMP-compliant.

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Fluid Bed Dryer (FBD)

Dries wet RMG output in 20–60 minutes. HEPA filtration, VFD blower, bag filter. Available 30 kg to 300 kg.

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Stage 2 — Drying Equipment

Equipment	Function	Note
Fluid Bed Dryer (FBD)	Dry wet granules from RMG — 20–60 min cycle, uniform LOD	Standard for wet granulation lines
Tray Dryer (TD)	Atmospheric hot-air drying — alternative to FBD for smaller operations	Lower cost, longer cycle time
Vacuum Tray Dryer (VTD)	Vacuum drying for heat-sensitive APIs	Optional — for specific formulations

Stage 3 — Sizing and Grading

Equipment	Function
Multi Mill	Mill dried granules to target particle size range
Vibro Sifter	Classify granules by sieve size — remove oversize and fines

Multi Mill

For milling dried granules after FBD. Available with impact and attrition heads. SS 316 contact parts.

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Vibro Sifter

Single and double deck vibro sifter for granule classification. SS 316, GMP-compliant.

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Stage 4 — Blending and Lubrication

Equipment	Function
Double Cone Blender (DCB)	Final lubrication blending — add Mg stearate, talc before compression
Octagonal Blender	Alternative to DCB for large batches or challenging formulations
IPC Bin / IPC Container	Closed transfer of blended granules from blender to tablet press

Double Cone Blender

Final lubrication blending. Available 50 L to 5000 L. SS 316 contact parts, butterfly valve discharge.

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IPC Bin / Container

Closed-system transfer of blended granules to tablet press. GMP-compliant, SS 316.

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Stage 5 — Tablet Compression

Equipment	Function
Single Punch Tablet Press	Lab/pilot scale compression — 1 punch, low output
Rotary Tablet Press (Multi-station)	Production scale — 8 to 45+ stations, high output
Tablet Deduster	Remove dust from compressed tablets before coating/packaging

Stage 6 — Tablet Coating (if coated tablets)

Equipment	Function
Coating Pan (Standard)	Sugar coating or small-batch film coating
Perforated Coating Pan	Film coating and enteric coating — faster drying, larger batches

Coating Pan

Standard and perforated coating pans for tablet film, sugar, and enteric coating. GMP-compliant, SS 316.

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Stage 7 — Supporting Utilities

Utility Equipment	Function
Purified Water System (RO/EDI)	Purified Water for binder preparation, cleaning, and testing
Clean Compressed Air System	Oil-free, dried, filtered instrument and process air
HVAC / AHU with HEPA	Maintain clean room conditions in manufacturing area
Dust Collection System	Control airborne powder in granulation and compression areas
Steam / Hot Water System	Heating medium for RMG jacket, FBD heater, vessel heating

Complete Tablet Plant — Equipment Cost Drivers

Batch size — larger batches require larger (more expensive) equipment
GMP target — WHO-GMP, US FDA, EU GMP add documentation and material requirements
Automation level — manual, semi-automatic, or fully automated PLC lines
Coating requirement — coated tablets add significant equipment investment
Product range — multi-product facilities need additional cleaning validation and IPC containers

Key Takeaway

A complete pharmaceutical tablet manufacturing plant requires matched, GMP-compliant equipment across all stages from granulation to packaging. Bipin Pharma Equipment manufactures the complete granulation, drying, milling, blending, and coating equipment for tablet plants. Contact us with your batch size and product range for a complete equipment proposal and free quote.

Tablet Plant Equipment

Rapid Mixer Granulator Fluid Bed Dryer Multi Mill Vibro Sifter Double Cone Blender Coating Pan

Tablet Plant — Key

Core LineRMG → FBD → MultiMill → Blender
GMP StdSchedule M / WHO-GMP
Key MaterialSS 316L
CoatingOptional (film/sugar/enteric)

Wet vs Dry Granulation How to Set Up Pharma Plant Pharma Equipment Buyers Guide All Articles

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Complete Equipment List for a Pharmaceutical Tablet Manufacturing Plant